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These findings were further supported by a 2025 systematic review and meta-analysis published in PMC , encompassing 16 studies and 5,997 patients, which confirmed semaglutides superior efficacy in reducing HbA1c and fasting blood glucose compared to dulaglutide
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Biochem Pharmacol (2013) 85:70517.10.1016/j.bcp.2012.11.016 33 CuadradoAMartin-MoldesZYeJLastres-BeckerI
Because it activates both of these receptors, it is called a dual GIP and GLP-1 receptor agonist
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Administered via the nasal passage, this combination potentially accelerates angiogenesis (the formation of new blood vessels), encourages the upregulation of actin and cellular motility, and boosts the expression of essential repair markers like VEGFR2 and EGR-1
